How Long Does Sperm Stay In Your Body? Before looking into the details of the what and how of plan b, let’s have a quick look of sperm and its travel inside a woman’s body. One way to find out how long a drug will last in your body is to measure its half-life. The half-life is the time it takes for half of the drug to be eliminated from the body. The half-life of hydrocodone is about four hours, the time in which half of it is no longer acting in your system. After five or six half-lives, the drug has been mostly eliminated but note that even at this point hydrocodone can be detected in the urine for up to three days. Knowing how long hydrocodone affects your system and how long it takes to eliminate it can help avoid dangerous interactions with other medications, side effects, and risk of overdose. Many factors influence how long a drug remains in your system. Body metabolism, physical condition, state of hydration, age, frequency and method of usage and tolerance will all affect your result. There are many factors that control clearance rates of hydrocodone and how long it will stay in a person’s system. Call The Recovery Village to learn more The half life of hydrocodone is about 4 hrs. This means it takes about a day to be out of your body. How Long Does Percocet Stay in your System. This varies depending on your body and how it is tested (urine, blood, hair, etc) but it can generally leave your system after a few days. Hydrocodone is taken by mouth (orally) and has to pass through your digestive system before you begin to feel its effects. You should start feeling the effects of hydrocodone in under an hour. The half-life of codeine is around three to four hours, which means that an entire dose of codeine will leave your system in approximately 16 hours or less.